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"Give with a free hand, but give only your own."
-- J.R.R. Tolkien The Children of Hurin
"Give with a free hand, but give only your own."
-- J.R.R. Tolkien The Children of Hurin
Memory Enhancement
I have nothing to sell you but hope, and that I give you for free.
The "Gerbil food cocktail"+ Choline [how much? From eggs, lecithin, or as a supplement]
+ Uridine monophosphate [how much or from what alternative source? orotates?]
+ DHA [How much? From fish oil]
(Without having any further guidance on how much of each and how often, and until we have more information, all we can do is go by supplement manufacturer's recommended dosages.]
Here's a thread about this that appeared on the Alz.org message board back in July of 2008:
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/4081064272?r=4531016513#4531016513
Here are the links to the articles and the associated journal article:
Get Smart About What You Eat And You
Might Actually Improve Your Intelligence
ScienceDaily (July 3, 2008)
New research findings published online in The FASEB Journal provide more evidence that if we get smart about what we eat, our intelligence can improve. According to MIT scientists, dietary nutrients found in a wide range of foods from infant formula to eggs increase brain synapses and improve cognitive abilities... In the study, gerbils were given various combinations of three compounds needed for healthy brain membranes: choline, found in eggs; uridine monophosphate (UMP) found in beets; and docosahexaenoic acid (DHA), found in fish oils. Other gerbils were given none of these to serve as a baseline. Then they were checked for cognitive changes four weeks later.
http://www.sciencedaily.com/releases/2008/07/080702150706.htm
ScienceDaily (July 3, 2008)
New research findings published online in The FASEB Journal provide more evidence that if we get smart about what we eat, our intelligence can improve. According to MIT scientists, dietary nutrients found in a wide range of foods from infant formula to eggs increase brain synapses and improve cognitive abilities... In the study, gerbils were given various combinations of three compounds needed for healthy brain membranes: choline, found in eggs; uridine monophosphate (UMP) found in beets; and docosahexaenoic acid (DHA), found in fish oils. Other gerbils were given none of these to serve as a baseline. Then they were checked for cognitive changes four weeks later.
http://www.sciencedaily.com/releases/2008/07/080702150706.htm
Cocktail Therapy For Alzheimer's
Disease? Works for Gerbils
ScienceDaily (July 9, 2008) — A dietary cocktail that includes a type of omega-3 fatty acid can improve memory and learning in gerbils, according to the latest study from MIT researchers that points to a possible beverage-based treatment for Alzheimer's and other brain diseases... The cocktail has previously been shown to promote growth of new brain connections in rodents.
"It may be possible to use this treatment to partially restore brain function in people with diseases that decrease the number of brain neurons, including, for example, Alzheimer's disease, Parkinson's, strokes and brain injuries."
The researchers found that normal gerbils treated with the mixture--a combination of DHA (a type of omega-3 fatty acid), uridine and choline--performed significantly better on learning and memory tests than untreated gerbils...
http://www.sciencedaily.com/releases/2008/07/080708155604.htm
Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils.
Sarah Holguin, Joseph Martinez, Camille Chow, and Richard Wurtman. FASEB Journal, July 7, 2008 DOI: 10.1096/fj.08-112425
http://dx.doi.org/10.1096/fj.08-112425
ScienceDaily (July 9, 2008) — A dietary cocktail that includes a type of omega-3 fatty acid can improve memory and learning in gerbils, according to the latest study from MIT researchers that points to a possible beverage-based treatment for Alzheimer's and other brain diseases... The cocktail has previously been shown to promote growth of new brain connections in rodents.
"It may be possible to use this treatment to partially restore brain function in people with diseases that decrease the number of brain neurons, including, for example, Alzheimer's disease, Parkinson's, strokes and brain injuries."
The researchers found that normal gerbils treated with the mixture--a combination of DHA (a type of omega-3 fatty acid), uridine and choline--performed significantly better on learning and memory tests than untreated gerbils...
http://www.sciencedaily.com/releases/2008/07/080708155604.htm
Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils.
Sarah Holguin, Joseph Martinez, Camille Chow, and Richard Wurtman. FASEB Journal, July 7, 2008 DOI: 10.1096/fj.08-112425
http://dx.doi.org/10.1096/fj.08-112425
There was then some discussion about where one would get the various ingredients of the "cocktail". Fish oil for DHA. Choline can be had as a supplement. The uridine was a problem.
Billsrunning added this post:
Uridine
as
a
supplement
is
not
directly available anywhere that I could find
but anything with "orotate" in it will metabolize to uridine. Magnesium
(Mg) Orotate is a good source of uridine and is readily available at
Amazon.com. Magnesium is advised widely for the AD brain. Moreover Mg.
orotate can be used with the DHA and choline.
In another thread called "The Ultimate Alzheimer's Cocktail" I must say, a year and a half later, seems even more interesting:
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/1891020913/p/1
Nutrient 'Cocktail' Appears to Improve
Dementia Symptoms
FRIDAY, Jan. 8, 2010 (HealthDay News) -- A combination of three nutrients might help improve memory in Alzheimer's patients by stimulating the growth of new brain connections (synapses), a new study shows.
Uridine, choline and the omega-3 fatty acid DHA (all found in breast milk) are precursors to the fatty molecules that make up brain cell membranes, which form synapses... In a clinical trial, 225 Alzheimer's patients were given a cocktail of the three nutrients, along with B vitamins, phosopholipids and antioxidants. Patients with mild Alzheimer's showed improvements in verbal memory...
http://news.yahoo.com/s/hsn/20100108/hl_hsn/nutrientcocktailappearstoimprovedementiasymptoms
Could Drink, Souvenaid, Be A Cure For Alzheimer's?
Study Will Determine Whether Nutrient-Laden Souvenaid Can Head Off Memory Loss
CHICAGO (CBS) Jan 11, 2010 8:45 pm US/Eastern
... It looks like a simple juice box, but inside there's a mixture called Souvenaid that could help Alzheimer's patients head off memory loss and possibly even improve their memory... "Souvenaid" contains vitamins and nutrients, including Uridine, fish oil components and Choline...
http://cbs4.com/health/Souvenaid.Alzheimers.drink.2.1419881.html
FRIDAY, Jan. 8, 2010 (HealthDay News) -- A combination of three nutrients might help improve memory in Alzheimer's patients by stimulating the growth of new brain connections (synapses), a new study shows.
Uridine, choline and the omega-3 fatty acid DHA (all found in breast milk) are precursors to the fatty molecules that make up brain cell membranes, which form synapses... In a clinical trial, 225 Alzheimer's patients were given a cocktail of the three nutrients, along with B vitamins, phosopholipids and antioxidants. Patients with mild Alzheimer's showed improvements in verbal memory...
http://news.yahoo.com/s/hsn/20100108/hl_hsn/nutrientcocktailappearstoimprovedementiasymptoms
Could Drink, Souvenaid, Be A Cure For Alzheimer's?
Study Will Determine Whether Nutrient-Laden Souvenaid Can Head Off Memory Loss
CHICAGO (CBS) Jan 11, 2010 8:45 pm US/Eastern
... It looks like a simple juice box, but inside there's a mixture called Souvenaid that could help Alzheimer's patients head off memory loss and possibly even improve their memory... "Souvenaid" contains vitamins and nutrients, including Uridine, fish oil components and Choline...
http://cbs4.com/health/Souvenaid.Alzheimers.drink.2.1419881.html
Here is a Yahoo search on one of the key ingredients 'uridine':
http://news.search.yahoo.com/news/search?ei=UTF-8&c=&p=uridine
There were some posts to the Alz.org medications forum about uridine and where to get it:
"Uridine
is
converted
to
CDP choline, but as Lucho said (which I agree with)
Alpha GPC is a superior acetylcholine precursor. Hence, uridine may be
redundant on the cocktail list and could be removed because of the
Alpha GPC. However, uridine does appear to help with DNA synthesis
which may warrant its use in addition to Alpha GPC."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/1891020913?r=2951072913#2951072913
Here are some links about a product with uridine. This is just information, and in no way should be construed as an endorsement.
http://www.lef.org/Vitamins-Supplements/Item00921/Cognitex-with-Neuroprotection-Complex.html
You can read about CDP-choline, and Alpha GPC too:
http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=4005&query=GPC&hiword=GPC%20
http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=5875&query=GPC&hiword=GPC%20
http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=8012&query=GPC&hiword=GPC%20
http://www.lef.org/magazine/mag2002/sep2002_cover_gpc_02.html
http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=4906&query=CDP&hiword=CDP%20
I think an MCT oil regimen should be added to this "cocktail" for people struggling with neurodegenerative diseases.
Attention, Couch Potatoes! Walking Boosts
Brain Connectivity, Function
ScienceDaily (Aug. 27, 2010) — A group of "professional couch potatoes," as one researcher described them, has proven that even moderate exercise -- in this case walking at one's own pace for 40 minutes three times a week -- can enhance the connectivity of important brain circuits, combat declines in brain function associated with aging and increase performance on cognitive tasks.
http://www.sciencedaily.com/releases/2010/08/100826141327.htm
ScienceDaily (Aug. 27, 2010) — A group of "professional couch potatoes," as one researcher described them, has proven that even moderate exercise -- in this case walking at one's own pace for 40 minutes three times a week -- can enhance the connectivity of important brain circuits, combat declines in brain function associated with aging and increase performance on cognitive tasks.
http://www.sciencedaily.com/releases/2010/08/100826141327.htm
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Updated: August 30, 2010
Inception: January 23, 2010