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"Give with a free hand, but give only your own."
 -- J.R.R. Tolkien The Children of Hurin
Patricia's Protocol
- Essentials -
An Effective Treatment for Corticobasal Degeneration?
(and other tauopathies?)

I have nothing to sell you but hope, and that I give you for free.

Not a cure, unfortunately, but rather a control.  This may be able to transform a terminal illness into a controlled condition, a death sentence into weekends of public service.

Alternative Treatment Protocol to Arrest the Progression of Tauopathies:
[...such as Alzheimer's disease, Progressive Supranuclear Palsy (PSP), Frontotemporal Dementia (FTD), Corticobasal Degeneration (CBD, corticobasal ganglionic degeneration, CBGD, corticobasal syndrome, CBS), etc]
  Tauopathy Discussion Forum

Patricia's Protocol:


Morning:
Cinnamon Extract      150mg                 Swansons (Cinnulin PF)
Curcumin              500mg                 Jarrow
Lecithin              2 tsp                 Now Foods (for choline)
Niacinamide           500mg                 Now Foods
Alpha-lipoic Acid     100mg                 Now Foods (ALA)
N-acetyl cysteine     600mg                 Now Foods (NAC)
Acetyl-L Carnitine    500mg                 Now Foods
MCT/Coconut oil       5 tsp  4:3 ratio      Now Foods or Ultimate Nutrition & Trop. Trad.

Mid-morning:
Fish oil              1 tsp                (for DHA)
CoQ10                 1 tsp (=300mg?)       Qunol (Costco)
Multivitamins         1 oz. (liquid)
B-12                  2500mcg (lozenge)    (Costco)

Afternoon:
Curcumin/piperine     330mg/3.5mg           Source Naturals
Garlic Extract        600mg                 Kyolic (300mg capsules)
Vitamin E             400IU                (For alpha-tocopherol)
Cinnamon Extract      ½ cup (“tea”)        (homemade)
Lecithin              2 tsp                 Now Foods (for choline)
MCT/Coconut oil       5 tsp    4:3 ratio    Now Foods or Ultimate Nutrition & Trop. Trad.

Evening:
Cinnamon Extract      150mg                 Swansons (Cinnulin)
Curcumin              500mg                 Jarrow
Niacinamide           500mg                 Now Foods
Alpha-lipoic Acid     100mg                 Now Foods (ALA)
N-acetyl cysteine     600mg                 Now Foods (NAC)
Acetyl-L Carnitine    500mg                 Now Foods
Magnesium             500mg                 Advance Research
Lecithin              2 tsp                 Now Foods (for choline)
MCT/Coconut oil       5 tsp 4:3 ratio       Now Foods or Ultimate Nutrition & Trop. Trad.
Vitamin D             1200IU (3 drops)      Biotics Research

Gerbil-food Cocktail (Souvenaide)
Uridine (from RNA of brewer's yeast or “orotate”)
Choline (from lecithin)
Docosahexaenoic acid (DHA from fish oil)

ATP Cocktail (Sinatra Solution):
CoQ10
L-carnitine
Magnesium
[D-ribose (not used due to questions about safety with CBD tau corruption)]

Indian Anti-oxidant Cocktail:
alpha-tocopherol (vitamin E)
N-acetyl cysteine (NAC)
Niacinamide

We are constantly looking for new things to try.  Therefore, the "protocol" gets modified.  Here are the previous lists...

Cinnamon:          1000mg (or the equivalent quantity of water-soluble extract)
                   three times per day, for the first 6 weeks, then at least twice
                   per day thereafter for maintenance.  Cinnamon in capsules form
                   prevents the degradation of the cinnamon by saliva.
                   If the person can't swallow capsules, it may be possible
                   to substitute
1/2 tsp of ground cinnamon in food for the 1000mg
                   capsules.  However, degradation of the cinnamon by saliva may
                   make this method less effective.
1/2 cup of "cinnamon tea" two
                   or three times per day could also be considered.  A commercial
                   water-soluble cinnamon extract called Cinnulin is also available
                   in capsule form.
                   Target:  Inhibition of tau protein aggregations, disassemble
                   aggregations that have already formed; improve glucose metabolism;
                   lower blood cholesterol levels.  May also inhibit H.pylori infection.

Curcumin:          300-500mg 2 to 3 times per day, at least 8 hours apart, if
                   possible.
  (~12mg/lb of body weight)
                   Target: Amyloid beta plaques, "oxidative stress" from iron and
                   copper, and possibly promoting neurogenesis.  At this dosage level,
                   it may also "normalize" blood pressure for those with high blood
                   pressure.


MCT/Coconut Oil:   1 tablespoon of coconut oil 2 times per day, 12 hours apart.
                   1 tablespoon of MCT oil 3 times per day, 8 hours apart, or
                   as close to that timing as practical.  Coconut oil may also be
                   dissolved in the MCT oil for convenience.  A 3:4 MCT/CO ratio
                   is a good starting point.
                   Mix in food.  Start out with a small amount and work up to a level
                   that is effective, but no more than needed.
                   Target: "Chronic brain starvation" or "type 3 diabetes".  Provides
                   neurons with alternative to glucose for a source of energy.
                  
See also Coconut Oil Recipes

Apple Juice:       2 cups per day.
                   May have a similar effect on amyloid beta plaques as curcumin (and Aricept?).

Magnesium Orotate: [quantity?] Magnesium is part of the Sinatra Solution adaptation for
                   neurodegenerative diseases.
                   Target:  Assist mitochondria with ATP production
                   -also-
                   The orotate part is said to be metabolized into uridine, which is
                   part of the Gerbil Food cocktail for memory enhancement [Need to check this!]

CoQ10:             100 mg 2x per day
                   Part of the Sinatra Solution
                   Target:  Assist
mitochondria with ATP production

Acetyl-L Carnitine:
Part of the Sinatra Solution
                   Target:  Assist
mitochondria with ATP production

Lecithin:          Granules.  1 Tbsp, 2x per day in food
                   Part of the Gerbil Food cocktail for memory enhancement
                   Lecithin provides choline.  It is found in eggs, or can be obtained as a
                   supplement, usually derived from soybeans.

DHA:              
From fish oil [quantity?  1 tsp liquid 1x per day]
                   Part of the Gerbil Food cocktail for memory enhancement


Optional supplements:

Resveratrol:        Target:  General health

Garlic:             Target:  General health

Grape Seed Extract:
Target:  Inhibition of tau protein aggregations, disassemble
                    aggregations that have already formed.


Niacinamide:        500mg, 3 times per day
                    Target:  Inhibition of tau protein aggregations, disassemble
                    aggregations that have already formed.


Lithium:???         60mg lithium orotate per day (1/2 of a 120mg tablet)
                    [???? not sure about this one.  Not using it at this time. 
                    In clinical trials using lithium to treat PSP, the study
                    participants dropped out due to side effects]
                    Target:  Prevent tau protein corruption, promoting neurogenesis.
                  

Methylene Blue:??? 1/2 cup of methylene blue solution, 2 times per day.  One (1)
                   drop
of 2.303% methylene blue solution, measured with a
                   medicine dropper, added to two cups of the cinnamon tea (or
                   other liquid).  Adjust the concentration as necessary to
                   maintain this ratio.
                   Target:  Inhibition of tau protein aggregations, disassemble
                   aggregations that have already formed, prevent neuronal
                   senescence. 
May also inhibit H.pylori infection.


***********

Give it a month.  You may be astounded by the results.  These things have worked so well for us that I just hope others will at least
give some of them a try.

If you don't try, there is no way in the world you will succeed.

Do not dismiss the medicinal qualities of foods.  Many of our drugs and medicines come from or originated in plants.  Aspirin, codeine, cocaine, nicotine, cannabis, alcohol, opium, digitalis, LSD and on and on and on all come from plants.  Used for good or for bad, there are chemicals from plants and animals
than can exert a powerful effect on the human body.

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Updated: June 2, 2010
Inception: April 30, 2008