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- Bexarotene -
General Information:
Names:
Wikipedia entry:
Dr. Ray Shahelien entry:
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Observations:
Bexarotene
Drug Quickly Reverses
Alzheimer's Symptoms in Mice
ScienceDaily (Feb. 9, 2012) — Neuroscientists at Case Western
Reserve University School of Medicine have made a dramatic
breakthrough in their efforts to find a cure for Alzheimer's
disease. The researchers' findings, published in the journal
Science, show that use of a drug in mice appears to quickly
reverse the pathological, cognitive and memory deficits caused
by the onset of Alzheimer's. The results point to the
significant potential that the medication, bexarotene, has to help the
roughly 5.4 million Americans suffering from the progressive
brain disease...
http://www.sciencedaily.com/releases/2012/02/120209144005.htm
ApoE-Directed Therapeutics
Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse
Models.
Paige E. Cramer, John R. Cirrito, Daniel W. Wesson, C. Y. Daniel
Lee, J. Colleen Karlo, Adriana E. Zinn, Brad T. Casali, Jessica
L. Restivo, Whitney D. Goebel, Michael J. James, Kurt R.
Brunden, Donald A. Wilson, and Gary E. Landreth.
Science, 9 February
2012 DOI: 10.1126/science.1217697
Abstract
Alzheimer's disease is associated with impaired clearance of
β-amyloid from the brain, a process normally facilitated by
apolipoprotein E (ApoE). ApoE expression is transcriptionally
induced through the action of the nuclear receptors peroxisome
proliferator activated receptor (PPARγ) and liver X receptors
(LXR) in coordination with retinoid X receptors (RXR). Oral
administration of the RXR agonist, bexarotene, to a murine model of Alzheimer's
disease resulted in enhanced clearance of soluble Aβ within
hours in an apoE-dependent manner. Aβ plaque area was reduced
>50% within just 72 hours. Furthermore, bexarotene stimulated
the rapid reversal of cognitive, social, and olfactory deficits
and improved neural circuit function. Thus, RXR activation
stimulates physiological Aβ clearance mechanisms, resulting in
the very rapid reversal of a broad range of Aβ-induced deficits.
http://www.sciencemag.org/content/early/2012/02/08/science.1217697
Wikipedia:
Bexarotene (tradenamed
Targretin) is an oral antineoplastic agent indicated by the FDA
(in 2000) for cutaneous T cell lymphoma.[1] It has been used
off-label for lung cancer,[2] breast cancer, and Kaposi's
sarcoma.
http://en.wikipedia.org/wiki/Bexarotene
The article pans the idea...
Alzheimer's treatment not the hoped for miracle
8 Aug 2012 5:24pm, EDT
Vitals on NBCNews.com
...Two papers out Wednesday in
the New England Journal of Medicine warn families of Alzheimer’s
victims not to seek treatment with Targretin (generic name:
bexarotene)...
http://vitals.nbcnews.com/_news/2012/08/08/13166642-alzheimers-treatment-not-the-hoped-for-miracle?lite
It's noteworthy how
"responsible media" publishes articles like this, but don't see
the need to include references. If there are "two papers",
well... what are the titles, authors, and where were they
published?
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Known sources:
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Natural sources:
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References:
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Updated: July 2, 2012
Inception: July 2, 2012